high-affinity ligand — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T13884	Shield-1		Others
	Shield-1 is a specific, high-affinity and cell-permeant ligand of FK506-binding protein-12 (FKBP), and reverses the instability by binding to mutated FKBP (mtFKBP), allowing conditional expression of mtFKBP-fused protein...		Others
TP1704	Galanin Receptor Ligand M35 TFA		Neuropeptide Y Receptor
	Galanin Receptor Ligand M35 TFA is a high-affinity ligand and antagonist of galanin receptor (Kd=0.1 nM).		Neuropeptide Y Receptor
T11349	GABAA receptor agent 1		GABA Receptor
	GABAA receptor agent 1 has strong anticonvulsant activity and is a high affinity ligand of GABAA receptor.		GABA Receptor
T7021	ZM241385		Adenosine Receptor
	ZM-241385 is a high-affinity antagonist ligand selective for the adenosine A2A receptor.		Adenosine Receptor
T7716	TNCA	Lycoperodine-1	Others
	TNCA (Lycoperodine-1) is a high-affinity CaSR ligand (CaSRL) with co-agonist activity.		Others
TP1496L	P5 Ligand for Dnak and DnaJ acetate	p5 Ligand for Dnak and DnaJ acetate(209518-24-1 free base)	HSP
	p5 Ligand for Dnak and DnaJ acetate is a nonapeptide. It is a high-affinity ligand for DnaK (E. coli Hsp70) and DnaJ (E. coli Hsp40).		HSP
TP1232L	Amylin, amide, rat acetate(124447-81-0,free base)		Amylin Receptor
	Amylin, amide, rat acetate is a potent and high affinity ligand of AMY1 and AMY3 receptors and variably of AMY2 receptors.		Amylin Receptor
T22782	FGIN-1-27		Others
	high affinity agonist of the translocator protein		Others
T16094	MK-3328		Others
	MK-3328 has a high affinity for β-Amyloid (IC50:10.5 nM), and can be used as a candidate PET ligand for clinical assessment of β-amyloid plaque load. MK-3328 is a potential treatment for Alzheimer's disease.		Others
TP1920L1	Acein acetate		RAAS
	Acein acetate is a high-affinity angiotensin-converting enzyme (ACE) ligand (Kd = 2.79 nM). Concentrations up to 500 nM had no significant effect on ACE enzyme activity. Enhanced NMDA + D-serine-induced dopamine release ...		RAAS
T15162	DPA-714		Others
	DPA-714 is a high affinity translocator protein (TSPO) ligand (Ki=7 nM). It is designed with a fluorine atom in its structure, allowing labelling with fluorine -18 and in vivo imaging using positron emission tomography. ...		Others
T9542	NS3861		AChR
	NS3861 is an agonist of nicotinic acetylcholine receptors (nAChRs) and bind with high affinity to heteromeric α3β4 and α4β2 nAChRs. NS3861 displays the β-subunit preference and a complete lack of activation at α4-contain...		AChR
T24334	L 687384	L687,384,L 687,384,L-687,384,L-687384,L687384
	L 687384 is a high-affinity ligand of sigma receptor.
T13745	KF21213		Histone Demethylase
	KF21213 shows a high affinity for the adenosine A2A receptors (Ki=3.0 nM). KF21213 is a highly selective ligand for mapping CNS adenosine A2A receptors.		Histone Demethylase
T30811	Cgp 12388	Cgp12388,Cgp-12388
	CGP 12388 is a radioactive ligand derived from a β-adrenergic receptor antagonist and is used for cardiac PET imaging due to its high hydrophilicity and affinity for β-adrenergic receptors.
T29030	U-101958 Maleate	U101958,U-101958,U 101958
	U-101958 Maleate is a ligand of dopamine D4 receptor. U-101958 Maleate also binds to a large sigma1 receptor-like component in SK-N-MC neuroblastoma cells and human cerebellum with high affinity.
T13813	PCSK9 ligand 1		Others
	PCSK9 ligand 1 is a small molecule ligand for proprotein convertase substilisin-like/kexin type 9 (PCSK9) and shows high affinity to PCSK9(Ki of 107 nM).		Others
T25367	EM-800	EM800,EM 800
	EM-800 is a high affinity ligand for estrogen receptor-α (ERα), the prodrug of EM-652. EM-800 independently inhibited the growth of E1-stimulated ZR-75-1 xenograft tumors in nude mice.
T13672	EC0489		Others
	EC0489, Small molecule-drug conjugate (SMDC) ,a conjugate of folic acid and desacetyl vinblastine hydrazide, is a high-affinity ligand for the folate receptor (FR). Refractory or metastatic Tumor.		Others
T16445	PD 144418		Sigma receptor
	PD 144418 displays potential antipsychotic activity. PD 144418 is a high affinity, potent and selective sigma 1 (σ1) receptor ligand (Ki: 0.08 nM and 1377 nM for σ1 and σ2 respectively). It shows devoid of any significan...		Sigma receptor